HD-MEA
# Single-cell activity analysis, axonal conduction, and propagation pattern analysis
We utilize High Density (HD) MEAs, comprised of tens of thousands to hundreds of thousands of microelectrodes, to analyze neuronal activity at the single-cell level. This approach enables detailed mechanistic explanations through analyses of single-cell compound responses, synaptic function, and axonal conduction.
Reference Papers
Yuan X, Schröter M, Obien MEJ, Fiscella M1, Gong W, Kikuchi T, Odawara A, Noji S, Suzuki I, Takahashi J, Hierlemann A, Frey U. Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level. Nature communication. 2020 11(1):4854.DOI
Brain Slice
A.Hasegawa, N.Matsuda, I. Suzuki, "Development of a Microelectrode Array System for Simultaneous Measurement of Field Potential and Glutamate Release in Brain Slices" Biosens. Bioelectron., 287, 2025, 117696 DOI
H.Takahashi, N.Matsuda, I. Suzuki, “Analysis of β rhythm induction in acute brain slices using field potential imaging with UHD-CMOS-MEA” bioRxiv, 2025, DOI
I. Suzuki*, N. Matsuda, X. Han, S. Noji, M. Shibata, N. Nagafuku, Y. Ishibashi, Large-area field potential imaging having single neuron resolution using 236,880 electrodes CMOS-MEA technology, Advanced Science, 2023, 1-23 DOI
Cardiomyocytes
N. Matsuda, N.Nagafuku, K.Matsuda, Y.Ishibashi, T.Taniguchi, Y.Matsuchita, N.Miyamoto, T.Yoshinaga, I.Suzuki, “Field potential Imaging in human iPSC- derived Cardiomyocytes using UHD-CMOS-MEA” bioRxiv, 2025, DOI
M. Osawa, Y. Fujita, K. Kagami, M. Ito, Y. Tamura, S. Tateishi , J. Take, F. Hirose, H. Hagiwara, K.e Imai, D. Yoshinaga, S. Baba, M. Osawa, H. Harashima, K. Murayama, Y. Akioka, A. Ohtake I. Suzuki, T. Adachi, T. Yamazaki, S. Arai, S. Matsumoto, T. K. Megumu K. Saito, I. Ohsawa and S. Nonoyama, “Cardiac dysfunction due to mitochondrial impairment assessed by human iPS cells caused by DNM1L mutations” Pediatric Research, 2025, 1-14, DOI